Metabolic syndrome and obesity
The gut microbiome plays a key role in metabolism, weight regulation, and energy balance. In the clinical practice of Han's United, metabolic disorders are among the actively treated conditions in a cohort of over 15,000 patients.
Important: FMT is not a "magic pill" for weight loss. It is an investigational method of influencing metabolism through the microbiome, complementing a healthy lifestyle.
What is metabolic syndrome?
A cluster of interrelated disorders that increase the risk of cardiovascular disease and type 2 diabetes.
About the syndrome
Metabolic syndrome is diagnosed when three or more of five criteria are present: abdominal obesity, elevated blood pressure, high blood sugar, low "good" cholesterol (HDL), and high triglycerides.
Statistics: Up to 25% of the adult population shows signs of metabolic syndrome. At the Han's United clinic, metabolic disorders are among the actively treated indications.
Syndrome components
- Abdominal obesity (waist circumference)
- Arterial hypertension
- Elevated fasting glucose
- Dyslipidemia (low HDL, high TG)
- Insulin resistance
Microbiome and metabolism
- The microbiome influences calorie extraction from food
- Gut bacteria regulate hunger and satiety hormones (GLP-1, PYY)
- Dysbiosis is linked to chronic systemic inflammation
- Short-chain fatty acids (butyrate) affect insulin sensitivity
Traditional approaches
Include lifestyle changes (diet, physical activity), pharmacotherapy (statins, metformin, antihypertensives).
Many patients struggle to maintain lifestyle changes. The microbiome may be the missing link in a comprehensive treatment approach.
Why FMT for metabolic syndrome?
Studies show that microbiome composition differs between people with normal weight and obesity. FMT may help restore metabolic balance.
Dysbiosis in obesity
Bacterial imbalance, low diversity
Metabolic disruptions
Inflammation, insulin resistance, fat accumulation
FMT from a healthy donor
Transplantation of a healthy microbiome
Improved metabolism
Better insulin sensitivity
Mechanism of action
A healthy microbiome improves short-chain fatty acid production (butyrate), reduces systemic inflammation, normalizes hunger hormone production (GLP-1, PYY), and improves intestinal barrier function.
Potential effects of FMT
- Improved insulin sensitivity
- Normalization of lipid profile
- Reduced inflammation markers
- Support for lifestyle changes
Realistic expectations: FMT is not a replacement for diet and physical activity. Studies show moderate effects on metabolic parameters. Results are individual.
Research results
FMT for metabolic syndrome is an actively developing field. At Han's United, metabolic disorders (obesity, type 2 diabetes, metabolic syndrome) are part of clinical practice.
+75%
Improvement in insulin sensitivity (Vrieze et al.)
15,000+
Patients in the Han's United cohort
6 wks
Duration of metabolic effect
AMC
Leading research center (Amsterdam)
Key studies
- Vrieze et al., Gastroenterology 2012: FMT from lean donors improved insulin sensitivity by 75% in patients with metabolic syndrome
- Kootte et al., Cell Metabolism 2017: The FMT effect is short-term but demonstrates the fundamental possibility of influencing metabolism through the microbiome
- Han's United clinical practice: Metabolic syndrome, type 2 diabetes, and obesity are among the conditions treated with FMT in a cohort of over 15,000 patients
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Patient story
Experience with a comprehensive approach to metabolic syndrome
"Metabolic syndrome plagued me for 5 years — high blood pressure, prediabetes, excess weight. Diets gave temporary results. After a course of FMT combined with a nutrition program, I noticed it became easier to control my appetite and weight. Over 4 months, my insulin levels improved, although it was a comprehensive approach."
Zhang W.
48 years old, Nanchang
Name changed. Results are individual.
Related conditions
FMT is also being studied for other metabolic and immune disorders
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Looking for a comprehensive approach?
If traditional methods are not producing results, contact us via Telegram or WhatsApp. A doctor will assess whether FMT could be part of your treatment program.
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China, Jiangxi Province, Shangrao City, Guangxin District, West Binjiang Road